Publications

Publications

Google Scholar

At Clark University

Nguyen, N.K.; Poduska, B.; Franks, M.; Bera, M.; MacCormack, I.; Lin, G.; Petroff, A.P.; Das, S.; Nag, A. A Copper-Selective Sensor and Its Inhibition of Copper-Amyloid Beta Aggregation. Biosensors 2024, 14, 247. https://doi.org/10.3390/bios14050247 Link

Kandler, R.; Benaragama, Y.; Bera, M.; Wang, C.; Samiha, R.A.; Sameera, W.M.C.; Das, S.*; Nag, A.* Development of Novel Immobilized Copper–Ligand Complex for Click Chemistry of Biomolecules. Molecules 2024, 29, 2148. https://doi.org/10.3390/molecules29092148 Link

Nag, A*, Das, S. Tetrazine cyclized peptides for one-bead-one-compound library: Synthesis and sequencing, Methods in Enzymology,  Academic Press,  2024,  ISSN 0076-6879, https://doi.org/10.1016/bs.mie.2024.04.015. https://authors.elsevier.com/a/1i%7EVVHRzCT-fn

Ul-Ain Q, Das S, Nguyen N, Poduska B, McAuliffe M, Franks M, et al. A library of copper-peptide/peptidomimetic complexes to explore the effect of ligand framework modification on electrocatalytic water oxidation. ChemRxiv. 2024; doi:10.26434/chemrxiv-2024-bpvvq This content is a preprint and has not been peer-reviewed. Link

Nag, A., Mafi, A., Das, S., Yu, M., Alvarez-Villalonga, B., Kim, S.K, Su, Y., Goddard, W., & Heath, J. (2023). Stereochemical engineering yields a multifunctional peptide macrocycle inhibitor of Akt2 by fine-tuning macrocycle-cell membrane interactions. Commun Chem 6, 95. Link

Borges, A., Nguyen, C., Letendre, M., Onasenko, I., Kandler, R., Nguyen, N. K., Chen, J., Allakhverdova, T., Atkinson, E., DiChiara, B., Wang, C., Petler, N., Patel, H., Nanavati, D., Das, S., Nag, A.* (2023) Facile de Novo Sequencing of Tetrazine-Cyclized Peptides through UV-Induced Ring-Opening and Cleavage from the Solid Phase ChemBioChem 24, e202200590. Link

Borges A., Onasenko I., Nag A.* (2022) Binding Characterization of Cyclic Peptide Ligands to Target Proteins and Chemical Epitopes Using ELISA and Fluorescence Polarization Assays. In: Coppock M.B., Winton A.J. (eds) Peptide Macrocycles. Methods in Molecular Biology, vol 2371. Humana, New York, NY. Link

Kandler, R., Das, S., Nag, A.* Copper-ligand clusters dictate size of cyclized peptide formed during alkyne-azide cycloaddition on solid support RSc. Advances, 2021, 11, 4842 - 4852, DOI: 10.1039/D0RA07491H Link Download

Nag, A.* and Das, S., Fluorescent Sensors of Phosphate Containing Biomolecules. Isr. J. Chem. 2020, https://doi.org/10.1002/ijch.202000087

Nag, A*, Das, S., Patent No. 63/075,630 Filed September 8, 2020

Borges, A., Gillespie, D., Nag A* Biological applications of amide and amino acid containing synthetic macrocycles, Supramolecular Chemistry, 2019, 31(8), 575-596, DOI: 10.1080/10610278.2019.1650178 Link Download

Ul-Ain, Q., Kandler, R., Gillespie, D., Nag, A.* "Chemical Epitope Targeting: Review of a Novel Screening Technology," Scholarly Undergraduate Research Journal at Clark, 2019, Vol. 5 , Article 4. Link Download

Ul-Ain Q, Kandler R, Gillespie D, Nag A* Chemical Epitope Targeting: Review of a Novel Screening Technology. J Med Chem Drug Des 2018, 1(2): dx.doi.org/10.16966/2578-9589.110 Link Download

Before Clark University

Henning, R.K., Varghese, J.O., Das, S., Nag, A., Tang, G., Tang, K., Sutherland, A.M., Heath, J.R.’Degradation of Akt Using Protein Catalyzed Capture Agents.’ Journal of Peptide Science, 2016, 22, 196-200. doi: 10.1002/psc.2858

Das, S.#, Nag, A.#, Liang, J., Bunck, D. N., Umeda, A., Farrow, B., Coppock, M. B., Sarkes, D. A., Finch, A. S., Agnew, H. D., Pitram, S., Heath, J. R. ‘A General Synthetic Approach for Designing Epitope Targeted Macrocyclic Peptide Ligands.’ Angewandte Chemie International Edition 2015, 54(45), 13219–13224. doi:10.1002/anie.201505243 (#equal contribution)

Farrow, B., Wong, M., Malette, J., Lai, B., Deyle, K. M., Das, S., Nag, A., Agnew, H. D. and Heath, J. R. ‘Epitope Targeting of Tertiary Protein Structure Enables Target-Guided Synthesis of a Potent In-Cell Inhibitor of Botulinum Neurotoxin.’ Angewandte Chemie International Edition 2015, 54(24), 7114–7119. doi:10.1002/anie.201502451

Deyle, K.M., Farrow, B., Hee, Y.Q., Work, J., Wong, M., Lai, B., Umeda, A., Millward, S.W., Nag, A., Das, S. and Heath, J.R. ‘Protein-targeting strategy used to develop a selective inhibitor of the E17K point mutation in the PH Domain of Akt1.’ Nature Chemistry 2015, 7(5), 455-462. doi:10.1038/nchem.2223

Nag, A., Das, S., Yu, M. B., Deyle, K. M., Millward, S. W. and Heath, J. R., ‘A Chemical Epitope Targeting Strategy for Protein Capture Agents: The Serine 474 Epitope of the Kinase Akt2.’ Angewandte Chemie International Edition 2013, 52(52), 13975–13979. doi: 10.1002/anie.201305882

Millward, S.W., Agnew, H.D., Lai, B., Lee, S.S., Lim, J., Nag, A., Pitram, S., Rohde, R. and Heath,J.R. ‘In situ click chemistry: from small molecule discovery to synthetic antibodies.’ Integrative Biology 2013, 5 (1), 87-95. doi: 10.1039/c2ib20110k

Millward, S.W., Henning, R.K., Kwong, G.A., Pitram, S., Agnew, H.D., Deyle, K.M., Nag, A., Hein, J., Lee, S.S., Lim, J., Pfeilsticker, J.A., Sharpless, K.B., Heath, J.R. ‘Iterative in situ click chemistry assembles a branched capture agent and allosteric inhibitor for Akt1.’ Journal of the American Chemical Society 2011, 133 (45), 18280-18288. doi: 10.1021/ja2064389

Agnew, H.D., Rohde, R.D., Millward, S.W., Nag, A., Yeo, W.S., Hein, J.E., Pitram, S.M., Tariq, A.A., Burns, V.M., Krom, R.J. and Fokin, V.V. Sharpless, K.B., Heath, J.R. ‘Iterative in situ click chemistry creates antibody-like protein-capture agents.’ Angewandte Chemie International Edition 2009, 48 (27), 4944-4948. doi: 10.1002/anie.200900488

Nag, A., Chakraborty, D., Chandra, A. ‘Effects of ion concentration on the hydrogen bonded structure of water in the vicinity of ions in aqueous NaCl solutions.’ Journal of Chemical Sciences 2008, 120(1), 71-77. doi: 10.1007/s12039-008-0009-0.

Patents:

Heath, J.R., Agnew, H., Farrow, B., Bunck, D., Liang, J., Nag, A., Das, S., Lai, B., Pitram, S., 2016. “Il-17f-specific capture agents, compositions, and methods of using and making” US 20170052199A1.

Heath, J.R., Henning, R., Ram, A.N., Das, S., Nag, A.” Cyclic peptide binder against oncogenic kras” US 20160264627 A1

Heath, J.R., Nag, A., Das, S., Deyle, K.M., Millward, S.W. and Kearney, P.E., Indi Molecular, Inc., 2016. Akt-specific capture agents, compositions, and methods of using and making. U.S. Patent 9,239,332.

Agnew, H., Rohde, R., Millward, S., Nag, A. and Heath, J.R., California Institute of Technology, 2015. Capture agents and related compositions, methods and systems. U.S. Patent 9,188,584.

Heath, J.R., Nag, A., Das, S., Varghese, J.O. and Henning, R.K., California Institute of Technology, 2014. Phosphorylated akt-specific capture agents, compositions, and methods of using and making. U.S. Patent Application 14/485,243.

Heath, J.R., Rohde, R.D., Nag, A., Das, S. and Umeda, A., California Institute of Technology, 2014. Cyclic peptides as protein targeting agents. U.S. Patent Application 14/310,201.