Publications
Google Scholar
At Clark University
Nag, A., Mafi, A., Das, S., Yu, M., Alvarez-Villalonga, B., Kim, S.K, Su, Y., Goddard, W., & Heath, J. (2023). Stereochemical engineering yields a multifunctional peptide macrocycle inhibitor of Akt2 by fine-tuning macrocycle-cell membrane interactions. Commun Chem 6, 95. Link
Borges, A., Nguyen, C., Letendre, M., Onasenko, I., Kandler, R., Nguyen, N. K., Chen, J., Allakhverdova, T., Atkinson, E., DiChiara, B., Wang, C., Petler, N., Patel, H., Nanavati, D., Das, S., Nag, A. (2023) Facile de Novo Sequencing of Tetrazine-Cyclized Peptides through UV-Induced Ring-Opening and Cleavage from the Solid Phase ChemBioChem 24, e202200590. Link
Borges A., Onasenko I., Nag A.* (2022) Binding Characterization of Cyclic Peptide Ligands to Target Proteins and Chemical Epitopes Using ELISA and Fluorescence Polarization Assays. In: Coppock M.B., Winton A.J. (eds) Peptide Macrocycles. Methods in Molecular Biology, vol 2371. Humana, New York, NY. Link
Kandler, R., Das, S., Nag, A.* (2021) Copper-ligand clusters dictate size of cyclized peptide formed during alkyne-azide cycloaddition on solid support RSc. Advances, 11, 4842 - 4852, DOI: 10.1039/D0RA07491H Link Download
Nag, A.* and Das, S. (2020), Fluorescent Sensors of Phosphate Containing Biomolecules. Isr. J. Chem. https://doi.org/10.1002/ijch.202000087
Nag, A*, Das, S., Patent No. 63/075,630 Filed September 8, 2020
Borges, A., Gillespie, D., Nag A* (2019) Biological applications of amide and amino acid containing synthetic macrocycles, Supramolecular Chemistry, 31:8, 575-596, DOI: 10.1080/10610278.2019.1650178 Link Download
Ul-Ain, Q., Kandler, R., Gillespie, D., Nag, A.* (2019) "Chemical Epitope Targeting: Review of a Novel Screening Technology," Scholarly Undergraduate Research Journal at Clark: Vol. 5 , Article 4. Link Download
Ul-Ain Q, Kandler R, Gillespie D, Nag A* (2018) Chemical Epitope Targeting: Review of a Novel Screening Technology. J Med Chem Drug Des 1(2): dx.doi.org/10.16966/2578-9589.110 Link Download
Before Clark University
Henning, R.K., Varghese, J.O., Das, S., Nag, A., Tang, G., Tang, K., Sutherland, A.M., Heath, J.R.’Degradation of Akt Using Protein Catalyzed Capture Agents.’ Journal of Peptide Science, 2016, 22, 196-200. doi: 10.1002/psc.2858
Das, S.#, Nag, A.#, Liang, J., Bunck, D. N., Umeda, A., Farrow, B., Coppock, M. B., Sarkes, D. A., Finch, A. S., Agnew, H. D., Pitram, S., Heath, J. R. ‘A General Synthetic Approach for Designing Epitope Targeted Macrocyclic Peptide Ligands.’ Angewandte Chemie International Edition 2015, 54(45), 13219–13224. doi:10.1002/anie.201505243 (#equal contribution)
Farrow, B., Wong, M., Malette, J., Lai, B., Deyle, K. M., Das, S., Nag, A., Agnew, H. D. and Heath, J. R. ‘Epitope Targeting of Tertiary Protein Structure Enables Target-Guided Synthesis of a Potent In-Cell Inhibitor of Botulinum Neurotoxin.’ Angewandte Chemie International Edition 2015, 54(24), 7114–7119. doi:10.1002/anie.201502451
Deyle, K.M., Farrow, B., Hee, Y.Q., Work, J., Wong, M., Lai, B., Umeda, A., Millward, S.W., Nag, A., Das, S. and Heath, J.R. ‘Protein-targeting strategy used to develop a selective inhibitor of the E17K point mutation in the PH Domain of Akt1.’ Nature Chemistry 2015, 7(5), 455-462. doi:10.1038/nchem.2223
Nag, A., Das, S., Yu, M. B., Deyle, K. M., Millward, S. W. and Heath, J. R., ‘A Chemical Epitope Targeting Strategy for Protein Capture Agents: The Serine 474 Epitope of the Kinase Akt2.’ Angewandte Chemie International Edition 2013, 52(52), 13975–13979. doi: 10.1002/anie.201305882
Millward, S.W., Agnew, H.D., Lai, B., Lee, S.S., Lim, J., Nag, A., Pitram, S., Rohde, R. and Heath,J.R. ‘In situ click chemistry: from small molecule discovery to synthetic antibodies.’ Integrative Biology 2013, 5 (1), 87-95. doi: 10.1039/c2ib20110k
Millward, S.W., Henning, R.K., Kwong, G.A., Pitram, S., Agnew, H.D., Deyle, K.M., Nag, A., Hein, J., Lee, S.S., Lim, J., Pfeilsticker, J.A., Sharpless, K.B., Heath, J.R. ‘Iterative in situ click chemistry assembles a branched capture agent and allosteric inhibitor for Akt1.’ Journal of the American Chemical Society 2011, 133 (45), 18280-18288. doi: 10.1021/ja2064389
Agnew, H.D., Rohde, R.D., Millward, S.W., Nag, A., Yeo, W.S., Hein, J.E., Pitram, S.M., Tariq, A.A., Burns, V.M., Krom, R.J. and Fokin, V.V. Sharpless, K.B., Heath, J.R. ‘Iterative in situ click chemistry creates antibody-like protein-capture agents.’ Angewandte Chemie International Edition 2009, 48 (27), 4944-4948. doi: 10.1002/anie.200900488
Nag, A., Chakraborty, D., Chandra, A. ‘Effects of ion concentration on the hydrogen bonded structure of water in the vicinity of ions in aqueous NaCl solutions.’ Journal of Chemical Sciences 2008, 120(1), 71-77. doi: 10.1007/s12039-008-0009-0.
Patents:
Heath, J.R., Agnew, H., Farrow, B., Bunck, D., Liang, J., Nag, A., Das, S., Lai, B., Pitram, S., 2016. “Il-17f-specific capture agents, compositions, and methods of using and making” US 20170052199A1.
Heath, J.R., Henning, R., Ram, A.N., Das, S., Nag, A.” Cyclic peptide binder against oncogenic kras” US 20160264627 A1
Heath, J.R., Nag, A., Das, S., Deyle, K.M., Millward, S.W. and Kearney, P.E., Indi Molecular, Inc., 2016. Akt-specific capture agents, compositions, and methods of using and making. U.S. Patent 9,239,332.
Agnew, H., Rohde, R., Millward, S., Nag, A. and Heath, J.R., California Institute of Technology, 2015. Capture agents and related compositions, methods and systems. U.S. Patent 9,188,584.
Heath, J.R., Nag, A., Das, S., Varghese, J.O. and Henning, R.K., California Institute of Technology, 2014. Phosphorylated akt-specific capture agents, compositions, and methods of using and making. U.S. Patent Application 14/485,243.
Heath, J.R., Rohde, R.D., Nag, A., Das, S. and Umeda, A., California Institute of Technology, 2014. Cyclic peptides as protein targeting agents. U.S. Patent Application 14/310,201.